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pentobarbital will lessen the level or outcome of methadone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.pentobarbital will lower the level or outcome of etonogestrel by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.pentobarbital will reduce the level or impact of conivaptan by affecting